R5010
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R5010
Sigma
Resveratrol
>99% (GC)
| Synonym: | 3,4′,5-Trihydroxy-trans-stilbene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol |
| CAS Number: | 501-36-0 |
| Linear Formula: | C14H12O3 |
| Molecular Weight: | 228.24 |
| MDL number: | MFCD00133799 |
| PubChem Substance ID: | 24278055 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Application | Selective inhibitor of COX−1. |
| Biochem/physiol Actions | Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-γ-activated receptor coactivator-1α (PGC-1α) and FOXO activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. |
Properties
| assay | >99% (GC) |
| Gene Information | human ... AR(367), CYP1A2(1544), ESR1(2099) |
| rat ... Esr1(24890) | |
| mouse ... Nos2(18126) | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| RTECS | CZ8987000 |
References
| reference | Jiang, W.J., Sirtuins: novel targets for metabolic disease in drug development. Biochem. Biophys. Res. Commun. 373, 341-344, (2008) Abstract |
| Raval, A.P., et al., Resveratrol and ischemic preconditioning in the brain. Curr. Med. Chem. 15, 1545-1551, (2008) Abstract | |
| Rayalam, S., et al., Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother Res. e-pub August 8, (2008) | |
| Tan, L., et al., Resveratrol exerts pharmacological preconditioning by activating PGC-1α. Med. Hypotheses e-pub August 9, (2008) |
